I have a Nostromo n52te and a Logitech G9 mouse.
Below you can see my keybinds to the Nostromo and what spells I cast using my mouse via VuhDo with no modifier, shift, alt, and ctrl key. I use the Logitech mouse buttons 4 and 5 for jumping and mounting. I use the directional pad on the Nostromo for Mumble only. The arrow keys are for movement with left and right be bound to strafe, of course. Reserved for the buttons on the screen I have Guardian of Ancient Kings and other lesser used abilities. Wheel up is Hand of Freedom and Wheel down is Hand of Protection. For retaliation my Nostromo setup is unchanged, but the spells cast via VuhDo are now offensive setup via the Hostile option.